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Neuroma Injection

Neuroma injections, guided by ultrasound, calm one specific painful nerve ending. They help Morton's neuroma, stump pain after amputation, and nerve pain after surgery, at Remix Medical in Houston, TX.

Neuroma Injection in Houston, Texas

When a nerve is cut or crushed, it tries to regrow. If it cannot find its way back to its target, the regenerating fibers coil into a disorganized tangle called a neuroma. That tangle fires on its own. Touch it and a bolt of pain shoots down the nerve's territory.

What is a Neuroma Injection?

A neuroma injection places local anesthetic — with or without corticosteroid — directly around the neuroma, typically under ultrasound guidance so the target can be visualized rather than guessed at.

It confirms the neuroma as the pain generator and, in many patients, quiets it for weeks to months. For a well-localized neuroma with reproducible tenderness, this is one of the more satisfying interventions in pain medicine, because the diagnosis is confirmed in real time.

StageWhat happens
BeforeYou're positioned, the skin is cleaned and numbed, and live imaging (fluoroscopy or ultrasound) guides the needle
DuringThe medication is placed precisely at the painful nerve growth (neuroma); most people feel pressure more than sharp pain
AfterYou rest briefly and go home the same day — arrange a driver if you received sedation

Where Neuromas Form

  • Morton's neuroma — between the metatarsal heads of the forefoot, causing burning pain and the sensation of a pebble in the shoe
  • Amputation stump neuromas — a leading contributor to residual limb pain and to phantom limb pain
  • Post-surgical neuromas — after hernia repair, knee replacement, thoracotomy, or breast surgery
  • Traumatic neuromas — following laceration or crush injury
  • Scar neuromas — where a cutaneous nerve is entrapped in scar tissue

Finding It

Examination is the diagnosis. A well-localized point of exquisite tenderness that, when tapped, produces electric pain radiating along the nerve's distribution — a positive Tinel's sign — is the classic finding. Ultrasound frequently visualizes the neuroma directly as a hypoechoic swelling in the nerve.

If anesthetic placed on that spot abolishes the pain, the question is answered.

Beyond the Injection

When injections provide reliable but short-lived relief, options include radiofrequency ablation of the nerve, cryoablation, chemical neurolysis, or surgical revision. For amputees, neuroma treatment is frequently the missing piece in an otherwise stalled prosthetic rehabilitation.

How it's performed

The neuroma is localized by palpation for a point of maximal tenderness with a positive Tinel's sign, then confirmed with ultrasound, which typically shows a hypoechoic swelling along the nerve. Under ultrasound guidance, a fine needle is advanced adjacent to the neuroma and local anesthetic, with or without corticosteroid, is deposited around it. Immediate abolition of the familiar pain confirms the neuroma as the pain generator.

How to prepare

No fasting required and you may drive yourself for most superficial injections. Hold anticoagulants only as directed by the prescribing physician. Point out the exact spot of maximal tenderness to your physician before the skin is prepped — your localization is the most valuable diagnostic information available.

What to expect after

Expect numbness in the nerve's distribution for several hours. Ice the site 20 minutes every 2 to 3 hours on the first day. Protect a numb foot or limb from injury and pressure until sensation returns. For Morton's neuroma, wear wide, low-heeled shoes. Monitor blood glucose if diabetic. Report fever, spreading redness, or skin breakdown.

Outcome

Immediate abolition of the familiar pain confirms the neuroma as the source. Corticosteroid frequently extends relief for weeks to months. Reliable but short-lived relief identifies candidates for radiofrequency ablation, cryoablation, or surgical revision.

Frequently asked

Neuroma Injection questions, answered

What is a neuroma injection?

It's an injection into a painful nerve growth called a neuroma, which forms when a nerve is injured or cut. The injection calms the nerve and reduces pain.

What does a neuroma feel like?

Usually a sharp, burning, or electric pain at a specific spot, sometimes with tingling. Pressing on the area often reproduces the pain.

How long does a neuroma injection last?

Relief varies from weeks to months and may be repeated. If injections give only short relief, other procedures may be considered.

Does the injection hurt?

The area is numbed first, so you'll mainly feel pressure. Some soreness afterward is normal.

What causes a neuroma?

It develops after nerve injury from surgery, trauma, or an amputation, as the healing nerve forms a tender knot. Not all neuromas are painful, but those that are can be treated.

SpecialtyPain ManagementTypeProcedureBody locationPeripheral nerve, residual limb, intermetatarsal space, surgical scar, cutaneous nerve branchesCPT code64455 (injection, anesthetic and/or steroid, plantar common digital nerve — Morton's neuroma); 64450 (injection, other peripheral nerve or branch); 64632 (destruction by neurolytic agent, plantar common digital nerve); 76942 (ultrasound guidance, when reported separately)

Also called Morton's Neuroma Injection, Stump Neuroma Injection, Peripheral Nerve Injection, Neuroma Block

This page is for general education and is not a substitute for medical advice. Whether a given procedure is appropriate depends on your individual evaluation. Contact a Remix Medical clinician to discuss your care.

Updated July 9, 2026. Medically reviewed by Raju Mantena, DO.

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