Gout is a kind of arthritis that results in swelling, inflammation, and server pain in the joints. The most common site of gout is the big toes, although other joints like the elbows, knees, ankles, and wrists can also be affected.
Gout tends to come on without warning, and cause significant discomfort. However, there are a number of medications that can be used to help alleviate this condition. These include Xanthine Oxidase Inhibitors, PEGylated uric acid-specific enzymes, and nonsteroidal anti-inflammatory drugs (NSAIDs). Although not all of these medications used to treat gout are suitable for those with kidney disease. Read on to find out more.
Gout treatment and kidney disease
Traditionally medical professionals have been concerned that common treatments for Gout may negatively impact those with kidney disease and make their condition worse.
Indeed, this can be seen in the use of NSAIDs. NSAIDs can help to reduce the pain and inflammation associated with gout flare-ups. They can also be used to prevent future attacks by reducing the amount of uric acid in the body.
However, NSAIDs can also cause kidney toxicity and hypertension. Something that means those with pre-existing kidney conditions should always check with a medical professional as to whether they should be taking these medications, even those that are available over the counter.
Additionally, new research shows that allopurinol is not only good for Gout because it helps to reduce the levels of uric acid in the blood, but can also benefit the kidneys. Indeed, this study shows that a may protect against chronic kidney disease rather than cause it.
Benefits/side effects of specific Gout Medications
Allopurinol
Benefits:
Allopurinol works by decreasing the amount of uric acid in the body, which helps to control gout attacks. Allopurinol can also help to reduce the risk of kidney stones.
Side effects:
Mild side effects of allopurinol include diarrhea, headaches, and a rash. More severe side effects of Allopurinol may include blood disorders or liver damage. To that end, if you have any unusual symptoms while taking you should contact your doctor immediately.
Uloric
Benefits:
The benefits of Uloric are two-fold. The first is that it works on the symptoms associated with gouts such as swelling and pain. While the second is that it lessens the levels of uric acid present in the blood. Thereby lowering the likelihood of a gout attack.
Side effects:
The side effects of Uloric include rashes, headaches, and diarrhea. While some people taking Uloric also experience vomiting and nausea. More serious side effects from Uloric can include allergic reactions, liver damage, and blood disorders. That is why it's vital you talk to your medical professional if you are taking this prescription medication and experience any side effects.
Krystexxa
Benefits:
Another popular prescription medication for the treatment of gout is Krystexxa. Krystexxa falls under the PEGylated uric acid specific enzyme class of drugs and consists of an artificially manufactured enzyme known as uricase.
Krystexxa breaks up uric acid, thereby relieving symptoms of gout and lessening the possibility of attacks in the future.
Side effects:
Those taking Krystexxa show similar side effects to the gout drugs mentioned above, including nausea and vomiting, headaches, and diarrhea. Sore throats are also a common lesser side effect of Krystexxa. Although it can also cause more severe side effects such as significant allergic reactions, low blood cell counts, and kidney problems, which means those with a pre-existing kidney condition need to check with a medical professional before taking it.
